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Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/414
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dc.contributor.authorCandia, Norma-
dc.contributor.authorLópez, Beatriz-
dc.contributor.authorZozio, Thierry-
dc.contributor.authorCarrivale, Marcela-
dc.contributor.authorDiaz, Chyntia-
dc.contributor.authorRussomando, Graciela-
dc.contributor.authorde Romero, Nilda J.-
dc.contributor.authorJara, Juan C.-
dc.contributor.authorBarrera, Lucía-
dc.contributor.authorRastogi, Nalin-
dc.contributor.authorRitacco, Viviana-
dc.date.accessioned2012-11-26T10:53:17Z-
dc.date.available2012-11-26T10:53:17Z-
dc.date.issued2007
dc.identifier.issn1471-2180
dc.identifier.urihttp://www.biomedcentral.com/content/pdf/1471-2180-7-75.pdf-
dc.identifier.urihttp://sgc.anlis.gob.ar/handle/123456789/414-
dc.descriptionBackground: We present a picture of the biodiversity of Mycobacterium tuberculosis in Paraguay, an inland South American country harboring 5 million inhabitants with a tuberculosis notification rate of 38/100,000. Results: A total of 220 strains collected throughout the country in 2003 were classified by spoligotyping into 79 different patterns. Spoligopatterns of 173 strains matched 51 shared international types (SITs) already present in an updated version of SpoIDB4, the global spoligotype database at Pasteur Institute, Guadeloupe. Our study contributed to the database 13 new SITs and 15 orphan spoligopatterns. Frequencies of major M. tuberculosis spoligotype lineages in our sample were as follows: Latin-American & Mediterranean (LAM) 52.3%, Haarlem 18.2%, S clade 9.5%, T superfamily 8.6%, X clade 0.9% and Beijing clade 0.5%. Concordant clustering by IS6110 restriction fragment length polymorphism (RFLP) and spoligotyping identified transmission in specific settings such as the Tacumbu jail in Asuncion and aboriginal communities in the Chaco. LAM genotypes were ubiquitous and predominated among both RFLP clusters and new patterns, suggesting ongoing transmission and adaptative evolution in Paraguay. We describe a new and successfully evolving clone of the Haarlem 3 sub-lineage, SIT2643, which is thus far restricted to Paraguay. We confirmed its clonality by RFLP and mycobacterial interspersed repetitive unit (MIRU) typing; we named it "Tacumbu" after the jail where it was found to be spreading. One-fifth of the spoligopatterns in our study are rarely or never seen outside Paraguay and one-tenth do not fit within any of the major phylogenetic clades in SpoIDB4. Conclusion: Lineages currently thriving in Paraguay may reflect local host-pathogen adaptation of strains introduced during past migrations from Europe.ES
dc.descriptionFil: Candia, Norma. Universidad Nacional de Asunción. Departamento de Biología Molecular; Paraguay.ES
dc.descriptionFil: López, Beatriz. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Biología Molecular; Argentina.ES
dc.descriptionFil: Zozio, Thierry. Institut Pasteur de Guadeloupe. Unité de la Tuberculose et des Mycobacteries; Francia.ES
dc.descriptionFil: Carrivale, Marcela.ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Biología Molecular; Argentina.ES
dc.descriptionFil: Diaz, Chyntia. Universidad Nacional de Asunción. Departamento de Biología Molecular; Paraguay.ES
dc.descriptionFil: Russomando, Graciela. Universidad Nacional de Asunción. Departamento de Biología Molecular; Paraguay.ES
dc.descriptionFil: de Romero, Nilda J. Laboratorio Central de Salud Pública; Paraguay.ES
dc.descriptionFil: Jara, Juan C. Programa Nacional de Control de la Tuberculosis; Paraguay.ES
dc.descriptionFil: Barrera, Lucía. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Biología Molecular; Argentina.ES
dc.descriptionFil: Rastogi, Nalin. Institut Pasteur de Guadeloupe. Unité de la Tuberculose et des Mycobacteries; Francia.ES
dc.descriptionFil: Ritacco, Viviana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Biología Molecular; Argentina.ES
dc.formatapplication/pdfES
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.sourceBMC Microbiology, 2007, 7(75).en_US
dc.subjectMycobacterium tuberculosisen_US
dc.subjectTuberculosisen_US
dc.subjectParaguayen_US
dc.titleFirst insight into Mycobacterium tuberculosis genetic diversity in Paraguayen_US
dc.typeArtículoes
dc.coveragePARen_US
anlis.essnrd1es
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairetypeArtículo-
item.fulltextWith Fulltext-
item.languageiso639-1en-
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