Please use this identifier to cite or link to this item:
http://sgc.anlis.gob.ar/handle/123456789/398
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ciapponi, Agustin | es |
dc.contributor.author | Bardach, Ariel | es |
dc.contributor.author | Glujovsky, Demian | es |
dc.contributor.author | Gibbons, Luz | es |
dc.contributor.author | Picconi, María Alejandra | es |
dc.date.accessioned | 2012-11-23T16:07:22Z | - |
dc.date.available | 2012-11-23T16:07:22Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0025493 | - |
dc.identifier.uri | http://sgc.anlis.gob.ar/handle/123456789/398 | - |
dc.description | Fil: Ciapponi, Agustin. Institute for Clinical Effectiveness and Health Policy (IECS); Argentina. | es |
dc.description | Fil: Bardach, Ariel. Institute for Clinical Effectiveness and Health Policy (IECS); Argentina. | es |
dc.description | Fil: Glujovsky, Demian. Institute for Clinical Effectiveness and Health Policy (IECS); Argentina. | es |
dc.description | Fil: Gibbons, Luz. Institute for Clinical Effectiveness and Health Policy (IECS); Argentina. | es |
dc.description | Fil: Picconi, María Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología. Servicio Virus Oncogénicos; Argentina. | es |
dc.description.abstract | Background: Cervical cancer is a major public health problem in Latin America and the Caribbean (LA&C), showing some of the highest incidence and mortality rates worldwide. Information on HPV type distribution in high-grade cervical lesions (HSIL) and invasive cervical cancer (ICC) is crucial to predict the future impact of HPV16/18 vaccines and screening programmes, and to establish an appropriate post-vaccinal virologic surveillance. The aim was to assess the prevalence of HPV types in HSIL and ICC in studies in LA&C. Methods and Findings: We performed a systematic review, following the MOOSE guidelines for systematic reviews of observational studies, and the PRISMA statement for reporting systematic reviews and meta-analyses. Inclusion criteria were at least ten cases of HSIL/ICC, and HPV-type elicitation. The search, without language restrictions, was performed in MEDLINE, Cochrane Library, EMBASE, LILACS from inception date to December 2009, proceedings, reference lists and consulting experts. A meta-analysis was performed using arc-sine transformations to stabilize the variance of simple proportions. Seventy-nine studies from 18 countries were identified, including 2446 cases of HSIL and 5540 of ICC. Overall, 46.5% of HSIL cases harbored HPV 16 and 8.9% HPV18; in ICC, 53.2% of cases harbored HPV 16 and 13.2% HPV 18. The next five most common types, in decreasing frequency, were HPV 31, 58, 33, 45, and 52. Study's limitations comprise the cross-sectional design of most included studies and their inherent risk of bias, the lack of representativeness, and variations in the HPV type-specific sensitivity of different PCR protocols. Conclusions: This study is the broadest summary of HPV type distribution in HSIL and ICC in LA&C to date. These data are essential for local decision makers regarding HPV screening and vaccination policies. Continued HPV surveillance would be useful, to assess the potential for changing type-specific HPV prevalence in the post-vaccination era in Latin America. | es |
dc.format | application/pdf | ES |
dc.language.iso | en | es |
dc.publisher | Yes | es |
dc.relation.ispartof | Plos one | es |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Creative Commons Attribution 4.0 International License | - |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.source | PloS One 2011; 6(10): e25493. | en_US |
dc.subject | Neoplasias | es |
dc.subject | Neoplasias del Cuello Uterino | es |
dc.subject | Infecciones por Papillomavirus | es |
dc.subject | América Latina | es |
dc.subject | Región del Caribe | es |
dc.title | Type-Specific HPV Prevalence in Cervical Cancer and High-Grade Lesions in Latin America and the Caribbean: Systematic Review and Meta-Analysis | es |
dc.type | Artículo | es |
dc.coverage | América Latina | en_US |
dc.coverage | Región del Caribe | en_US |
dc.coverage | Región del Caribe | en_US |
dc.identifier.doi | 10.1371/journal.pone.0025493. | - |
anlis.essnrd | 1 | es |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | Artículo | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.dept | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
crisitem.author.dept | Departamento de Virología | - |
crisitem.author.dept | Servicio Virus Oncogénicos | - |
crisitem.author.parentorg | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.parentorg | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
crisitem.author.parentorg | Departamento de Virología | - |
Appears in Collections: | snrd Publicaciones INEI |
Files in This Item:
File | Description | Size | Format | |
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PloSOne,2011,6(10), e25493.pdf | Artículo en inglés | 1.01 MB | Adobe PDF | View/Open |
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