Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/369
DC FieldValueLanguage
dc.contributor.authorMelano, Roberto-
dc.contributor.authorCorso, Alejandra-
dc.contributor.authorPetroni, Alejandro-
dc.contributor.authorCentrón, Daniela-
dc.contributor.authorOrman, Betina E.-
dc.contributor.authorPereyra, Adriana-
dc.contributor.authorMoreno, Noemí-
dc.contributor.authorGalas, Marcelo F.-
dc.date.accessioned2012-11-18T16:20:19Z-
dc.date.available2012-11-18T16:20:19Z-
dc.date.issued2003-
dc.identifier.issn1460-2091-
dc.identifier.urihttp://sgc.anlis.gob.ar/handle/123456789/369-
dc.identifier.urihttp://jac.oxfordjournals.org/content/52/1/36.full.pdf+html-
dc.descriptionKlebsiella pneumoniae M1803, isolated from a paediatric patient with chronic urinary infection, presented nine antimicrobial resistance mechanisms harboured on two conjugative megaplasmids, in addition to the chromosomally mediated SHV-1 beta-lactamase. These nine antimicrobial resistance mechanisms comprised two extended-spectrum beta-lactamases (ESBLs) (PER-2 and CTX-M-2), TEM-1-like, OXA-9-like, AAC(3)-IIa, AAC(6')-Ib, ANT(3")-Ia and resistance determinants to tetracycline and chloramphenicol. During fluoroquinolone treatment, a variant derived from M1803 (named M1826) was selected, with an overall increase of MICs, in particular of cefoxitin and carbapenems. No enzymic activity against these latter drugs was found. Mutations in the region analogous to the quinolone resistance-determining region were not found. Strain M1826 was deficient in OmpK35/36 expression, which produced the decrease in the susceptibility to cefoxitin, carbapenems and fluoroquinolones. The blaCTX-M-2 gene was located in an unusual class 1 integron, which includes Orf513, as occurred in the recently described In35. In addition, Tn3 and Tn1331 were detected in both K. pneumoniae isolates. This is the first report of in vivo selection of an OmpK35/36 deficiency in a K. pneumoniae strain that produced a novel combination of two ESBLs (CTX-M-2 and PER-2) during fluoroquinolone treatment in a paediatric patient with chronic urinary infection.ES
dc.descriptionFil: Melano, Roberto. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio de Antimicrobianos; Argentina.ES
dc.descriptionFil: Corso, Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio de Antimicrobianos; Argentina.ES
dc.descriptionFil: Petroni, Alejandro. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio de Antimicrobianos; Argentina.ES
dc.descriptionFil: Centrón, Daniela. Universidad de Buenos Aires. Departamento de Microbiología; Argentina.ES
dc.descriptionFil: Orman, Betina. Universidad de Buenos Aires. Departamento de Microbiología; Argentina.ES
dc.descriptionFil: Pereyra, Adriana. Hospital Gobernador Centeno. Servicio de Bacteriología; Argentina.ES
dc.descriptionFil: Moreno, Noemí. Hospital Gobernador Centeno. Servicio de Bacteriología; Argentina.ES
dc.descriptionFil: Galas, Marcelo F. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio de Antimicrobianos; Argentina.ES
dc.formatapplication/pdfES
dc.language.isoengen_US
dc.rights2004-05-29en_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.sourceJournal of Antimicrobial Chemotherapy, 2003, 52(1), 36–42.en_US
dc.subjectFarmacorresistencia Bacteriana Múltipleen_US
dc.subjectKlebsiella pneumoniaeen_US
dc.subjectbeta-Lactamasasen_US
dc.subjectArgentinaen_US
dc.titleMultiple antibiotic-resistance mechanisms including a novel combination of extended-spectrum beta-lactamases in a Klebsiella pneumoniae clinical strain isolated in Argentinaen_US
dc.typeArtículoes
dc.coverageARGen_US
anlis.essnrd1es
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.grantfulltextopen-
crisitem.author.deptPublic Health Ontario Laboratory-
crisitem.author.deptMaestría en Microbiología Molecular UNSM-ANLIS-
crisitem.author.deptServicio Antimicrobianos-
crisitem.author.deptDepartamento de Bacteriología-
crisitem.author.deptInstituto Nacional de Enfermedades Infecciosas (INEI)-
crisitem.author.deptAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.deptServicio Antimicrobianos-
crisitem.author.deptDepartamento de Bacteriología-
crisitem.author.deptInstituto Nacional de Enfermedades Infecciosas (INEI)-
crisitem.author.deptAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.orcid0000-0003-1177-7037-
crisitem.author.parentorgCentro Nacional Red de Laboratorios (CNRL)-
crisitem.author.parentorgDepartamento de Bacteriología-
crisitem.author.parentorgInstituto Nacional de Enfermedades Infecciosas (INEI)-
crisitem.author.parentorgAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.parentorgDepartamento de Bacteriología-
crisitem.author.parentorgInstituto Nacional de Enfermedades Infecciosas (INEI)-
crisitem.author.parentorgAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
Appears in Collections:snrd
Publicaciones INEI
Files in This Item:
File Description SizeFormat
Melano_multipleantibiotic.pdfPDF1.74 MBAdobe PDFThumbnail
View/Open
Show simple item record

Page view(s)

6
checked on Feb 16, 2020

Download(s)

5
checked on Feb 16, 2020

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.