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Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/294
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dc.contributor.authorVan Deun, A.-
dc.contributor.authorBarrera, Lucía-
dc.contributor.authorBastian, I.-
dc.contributor.authorFattorini, L.-
dc.contributor.authorHoffmann, H.-
dc.contributor.authorKam, Kai Man-
dc.contributor.authorRigouts, Leen-
dc.contributor.authorRuesch-Gerdes, S.-
dc.contributor.authorWright, A.-
dc.date.accessioned2012-10-31T00:44:57Z-
dc.date.available2012-10-31T00:44:57Z-
dc.date.issued2009-
dc.identifier.issn1098-660X-
dc.identifier.urihttp://jcm.asm.org/content/47/11/3501.full.pdf+html-
dc.identifier.urihttp://sgc.anlis.gob.ar/handle/123456789/294-
dc.descriptionThe objectives of this study were to investigate the origin of highly discordant rifampin (rifampicin) (RMP) drug susceptibility test results obtained for Mycobacterium tuberculosis strains during proficiency testing. Nine Supra-National Tuberculosis Reference Laboratories tested the RMP susceptibilities of 19 selected M. tuberculosis strains, using standard culture-based methods. The strains were classified as definitely resistant (R) (n 6) or susceptible (S) (n 2) or probably resistant (PR) (n 8) or susceptible (PS) (n 3) based on rpoB mutations and treatment outcome. All methods yielded a susceptible result for the two S and three PS strains lacking an rpoB mutation and a resistant result for one R strain with a Ser531Leu mutation and one PR strain with a double mutation. Although the remaining 12 R and PR strains had rpoB mutations (four Asp516Tyr, three Leu511Pro, two Leu533Pro, one each His526Leu/Ser, and one Ile572Phe), they were all susceptible by the radiometric Bactec 460TB or Bactec 960 MGIT methods. In contrast, only one was susceptible by the proportion method on Lo¨wenstein-Jensen medium and two on Middlebrook 7H10 agar. Low-level but probably clinically relevant RMP resistance linked to specific rpoB mutations is easily missed by standard growth-based methods, particularly the automated broth-based systems. Further studies are required to confirm these findings, to determine the frequency of these low-level-resistant isolates, and to identify technical improvements that may identify such strains.ES
dc.descriptionFil: Van Deun, A. Institute of Tropical Medicine. Mycobacteriology Unit; Bélgica.ES
dc.descriptionFil: Barrera, Lucía. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio de Micobacterias; Argentina.ES
dc.descriptionFil: Bastian, I. Institute of Medical and Veterinary Science; Australia.ES
dc.descriptionFil: Fattorini, L. Istituto Superiore di Sanita; Italia.ES
dc.descriptionFil: Hoffmann, H. IML-Gauting; Alemania.ES
dc.descriptionFil: Kam, K. M. Centre for Health Protection; China.ES
dc.descriptionFil: Rigouts, L. Institute of Tropical Medicine. Mycobacteriology Unit; Bélgica.ES
dc.descriptionFil: Ruesch-Gerdes, S. Forschungszentrum Borstel; Alemania.ES
dc.descriptionFil: Wright, A. World Health Organization; Suiza.ES
dc.formatapplication/pdfES
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.sourceJournal of Clinical Microbiology, 2009, 47(11), 3501–3506.en_US
dc.subjectMycobacterium tuberculosisen_US
dc.subjectRifampinen_US
dc.titleMycobacterium tuberculosis Strains with Highly Discordant Rifampin Susceptibility Test Resultsen_US
dc.typeArtículoes
anlis.essnrd1es
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairetypeArtículo-
item.fulltextWith Fulltext-
item.languageiso639-1en-
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