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dc.contributor.authorBok, Karin-
dc.contributor.authorMatson, David O.-
dc.contributor.authorGomez, Jorge A.-
dc.date.accessioned2012-10-30T13:23:43Z-
dc.date.available2012-10-30T13:23:43Z-
dc.date.issued2002-
dc.identifier.issn1098-660X-
dc.identifier.urihttp://sgc.anlis.gob.ar/handle/123456789/285-
dc.identifier.urihttp://jcm.asm.org/content/40/6/2016.full.pdf+html-
dc.descriptionRotavirus is the most-common cause of severe diarrhea in young children. Complete rotavirus characterization includes determination of the antigenic type of the two outer capsid proteins, VP7 and VP4, designated G and P types, respectively. During a nationwide rotavirus surveillance study, genotype G4 frequency increased during the second year. To evaluate further the mechanism of emergence and the relationship among G4 strains, the genetic diversity of VP7 capsid protein in these samples was studied in detail. Overall nucleotide sequence divergence ranged from less than 0.1 to 19.5%, a higher divergence than that observed for other rotavirus G types (0.1 to 9%). Sequences were classified into two major lineages (designated I and II) based on their nucleotide distances. The most heterogeneous lineage was further subdivided into four sublineages (designated Ia to Id). Most Argentine sequences were of sublineages Ib and Ic, which were confirmed to be independent sequence clusters by parsimony analysis. This study describes different lineages and sublineages within G4 strains and shows that Argentine strains are distantly related to reference strain ST3. The appearance of at least two G4 genotype (sub)lineages during 1998 demonstrates that the increased frequency of these strains was due to the synchronized emergence of different groups of strains.ES
dc.descriptionFil: Bok, Karin. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Laboratorio de Gastroenteritis Virales; Argentina.ES
dc.descriptionFil: Matson, David O. Eastern Virginia Medical School. Center for Pediatric Research, Children’s Hospital of The King’s Daughters; Estados Unidos.ES
dc.descriptionFil: Gomez, Jorge A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Laboratorio de Gastroenteritis Virales; Argentina.ES
dc.formatapplication/pdfES
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.sourceJournal of Clinical Microbiology, 2002, 40(6), 2016–2022.en_US
dc.subjectRotavirusen_US
dc.subjectInfecciones por Rotavirusen_US
dc.subjectVariación Genéticaen_US
dc.subjectGenotipoen_US
dc.subjectHumanosen_US
dc.subjectArgentinaen_US
dc.titleGenetic variation of capsid protein VP7 in genotype g4 human rotavirus strains: simultaneous emergence and spread of different lineages in Argentinaen_US
dc.typeArtículoes
dc.coverageARGen_US
anlis.essnrd1es
item.grantfulltextopen-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.openairetypeArtículo-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
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