Please use this identifier to cite or link to this item:
http://sgc.anlis.gob.ar/handle/123456789/2237
DC Field | Value | Language |
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dc.contributor.author | Basile, Juan Ignacio | es |
dc.contributor.author | Geffner, Laura | es |
dc.contributor.author | Romero, María Mercedes | es |
dc.contributor.author | Balboa, Luciana | es |
dc.contributor.author | Sabio y García, Carmen Alejandra | es |
dc.contributor.author | Ritacco, Viviana | es |
dc.contributor.author | García, Ana | es |
dc.contributor.author | Cuffré, Mónica | es |
dc.contributor.author | Abbate, Eduardo | es |
dc.contributor.author | López, Beatriz | es |
dc.contributor.author | Barrera, Lucía | es |
dc.contributor.author | Ambroggi, Marta | es |
dc.contributor.author | Alemán, Mercedes | es |
dc.contributor.author | Sasiain, María C. | es |
dc.contributor.author | de la Barrera, Silvia | es |
dc.date.accessioned | 2021-01-22T19:31:27Z | - |
dc.date.available | 2021-01-22T19:31:27Z | - |
dc.date.issued | 2011-10-01 | - |
dc.identifier.issn | 1537-6613 | - |
dc.identifier.uri | http://sgc.anlis.gob.ar/handle/123456789/2237 | - |
dc.description | Fil: Basile, Juan I. Academia Nacional de Medicina. Instituto de Investigaciones Hematológicas Mariano R. Castex; Argentina. | es |
dc.description | Fil: Geffner, Laura J. Academia Nacional de Medicina. Instituto de Investigaciones Hematológicas Mariano R. Castex; Argentina. | es |
dc.description | Fil: Romero, María M. Academia Nacional de Medicina. Instituto de Investigaciones Hematológicas Mariano R. Castex; Argentina. | es |
dc.description | Fil: Balboa, Luciana. Academia Nacional de Medicina. Instituto de Investigaciones Hematológicas Mariano R. Castex; Argentina. | es |
dc.description | Fil: Sabio y García, Carmen. Academia Nacional de Medicina. Instituto de Investigaciones Hematológicas Mariano R. Castex; Argentina. | es |
dc.description | Fil: Ritacco, Viviana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. | es |
dc.description | Fil: García, Ana. Hospital Muñíz. Instituto de Tisioneumonologías; Argentina. | es |
dc.description | Fil: Cuffré, Mónica. Hospital Muñíz. Instituto de Tisioneumonologías; Argentina. | es |
dc.description | Fil: Abbate, Eduardo. Hospital Muñíz. Instituto de Tisioneumonologías; Argentina. | es |
dc.description | Fil: López, Beatriz. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. | es |
dc.description | Fil: Barrera, Lucía. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. | es |
dc.description | Fil: Ambroggi, Marta. Hospital Muñíz. Instituto de Tisioneumonologías; Argentina. | es |
dc.description | Fil: Alemán, Mercedes. Academia Nacional de Medicina. Instituto de Investigaciones Hematológicas Mariano R. Castex; Argentina. | es |
dc.description | Fil: Sasiain, María C. Academia Nacional de Medicina. Instituto de Investigaciones Hematológicas Mariano R. Castex; Argentina. | es |
dc.description | Fil: de la Barrera, Silvia S. Academia Nacional de Medicina. Instituto de Investigaciones Hematológicas Mariano R. Castex; Argentina. | es |
dc.description.abstract | Background. The proinflammatory cytokine interleukin 17 (IL-17) plays an important role in immune responses but it is also associated with tissue-damaging inflammation. So, we evaluated the ability of Mycobacterium tuberculosis clinical isolates to induce IL-17 in tuberculosis (TB) patients and in healthy human tuberculin reactors (PPD1HD). Methods. IL-17, interferon c (IFN-c), and interleukin 23 (IL-23) receptor expression were evaluated ex vivo and cultured peripheral blood mononuclear cells from TB and PPD1HD stimulated with irradiated clinical isolates from multidrug resistant (MDR) outbreaks M (Haarlem family) and Ra (Latin American–Mediterranean family), as well as drug-susceptible isolates belonging to the same families and laboratory strain H37Rv for 48 hours in T-cell subsets by flow cytometry. Results. We observed that: (1) MDR strains M and Ra are stronger IL-17 inducers than drug-susceptible Mtb strains of the Haarlem and Latin American–Mediterranean families, (2) MDR-TB patients show the highest IL-17 expression that is independent on the strain, (3) IL-17 expression is dependent on CD41 and CD81 T cells associates with persistently high antigen load. Conclusions. IL-17–producing T cells could play an immunopathological role in MDR-TB promoting severe tissue damage, which may be associated with the low effectiveness of the second-line drugs employed in the treatment. | es |
dc.format | - | |
dc.language.iso | en | es |
dc.relation.ispartof | The Journal of infectious diseases | es |
dc.rights | Open Access | - |
dc.rights | Creative Commons Attribution 4.0 International License | - |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.source | The Journal of Infectious Diseases 2011;204(7):1054-1064 | - |
dc.subject | Mycobacterium tuberculosis | es |
dc.subject | Tuberculosis | es |
dc.subject | Interleucina-17 | es |
dc.subject | Linfocitos T | es |
dc.title | Outbreaks of mycobacterium tuberculosis MDR strains induce high IL-17 T-cell response in patients with MDR tuberculosis that is closely associated with high antigen load | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1093/infdis/jir460 | - |
anlis.essnrd | 1 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | Artículo | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
Appears in Collections: | Publicaciones INEI |
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TheJournalofInfectiousDiseases_2011_204_7_p1054-p1064.pdf | 447.38 kB | Adobe PDF | View/Open |
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