Please use this identifier to cite or link to this item:
http://sgc.anlis.gob.ar/handle/123456789/2197
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Monteserin, Johana | es |
dc.contributor.author | Pérez-Lago, Laura | es |
dc.contributor.author | Yokobori, Noemi | es |
dc.contributor.author | Paul, Roxana | es |
dc.contributor.author | Rodríguez Maus, Sandra | es |
dc.contributor.author | Simboli, Norberto | es |
dc.contributor.author | Eldholm, Vegard | es |
dc.contributor.author | López, Beatriz | es |
dc.contributor.author | Garcia de Viedma, Dario | es |
dc.contributor.author | Ritacco, Viviana | es |
dc.date.accessioned | 2021-01-20T13:27:52Z | - |
dc.date.available | 2021-01-20T13:27:52Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0002-9637 | - |
dc.identifier.uri | http://sgc.anlis.gob.ar/handle/123456789/2197 | - |
dc.description | Fil: Monteserin, Johana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. | es |
dc.description | Fil: Pérez-Lago, Laura. Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España. | es |
dc.description | Fil: Yokobori, Noemí. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. | es |
dc.description | Fil: Paul, Roxana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. | es |
dc.description | Fil: Rodríguez Maus, Sandra. Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España. | es |
dc.description | Fil: Simboli, Norberto. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. | es |
dc.description | Fil: Eldholm, Vegard. Norwegian Institute of Public Health, Oslo; Noruega. | es |
dc.description | Fil: López, Beatriz. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. | es |
dc.description | Fil: García de Viedma, Darío. Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España. | es |
dc.description | Fil: Ritacco, Viviana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. | es |
dc.description.abstract | Two Mycobacterium tuberculosis strains-M (sublineage 4.1) and Ra (sublineage 4.3)-have long prevailed in Argentina among patients with multidrug-resistant tuberculosis (MDR-TB). Recently, budget constraints have hampered the surveillance of MDR-TB transmission. Based on whole-genome sequence analysis, we used M- and Ra-specific single nucleotide polymorphisms to tailor two multiplex allele-specific polymerase chain reactions (PCRs), which we applied to 252 stored isolates (95% of all newly diagnosed MDR-TB cases countrywide, 2015-2017). Compared with the latest data available (2007-2009), the M strain has receded (80/324 to 20/252, P < 0.0001), particularly among cross-border migrants (12/58 to 0/53, P = 0.0003) and HIV-infected people (30/97 to 7/74, P = 0.0007), but it still accounts for 4/12 new cases of extensively drug-resistant TB. Differently, the Ra strain remained stable in frequency (39/324 to 33/252) and contributed marginally to the extensive drug-resistance load (1/12). Our novel strategy disclosed recent trends of the two major MDR-TB strains, providing meaningful data to allocate control interventions more efficiently. | es |
dc.format | - | |
dc.language.iso | en | es |
dc.publisher | American Society of Tropical Medicine and Hygiene | es |
dc.relation.ispartof | The American journal of tropical medicine and hygiene | es |
dc.rights | Open Access | - |
dc.rights | Creative Commons Attribution 4.0 International License | - |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.source | The American Journal of Tropical Medicine and Hygiene 2019; 101(6):1308-1311. | - |
dc.subject | Mycobacterium tuberculosis | es |
dc.subject | Argentina | es |
dc.title | Trends of Two Epidemic Multidrug-Resistant Strains of Mycobacterium tuberculosis in Argentina Disclosed by Tailored Molecular Strategy | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.4269/ajtmh.19-0397 | - |
anlis.essnrd | 1 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | Artículo | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Maestría en Microbiología Molecular UNSM-ANLIS | - |
crisitem.author.parentorg | Centro Nacional Red de Laboratorios (CNRL) | - |
Appears in Collections: | Publicaciones INEI |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
10.4269_ajtmh.19-0397..pdf | Artículo en inglés | 280.49 kB | Adobe PDF | View/Open |
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This item is licensed under a Creative Commons License