Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/218
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dc.contributor.authorPetroni, Alejandroes
dc.contributor.authorCorso, Alejandraes
dc.contributor.authorMelano, Robertoes
dc.contributor.authorCacace, María Luisaes
dc.contributor.authorBru, Ana Maríaes
dc.contributor.authorRossi, Aliciaes
dc.contributor.authorGalas, Marcelo F.es
dc.date.accessioned2012-10-18T03:55:01Z-
dc.date.available2012-10-18T03:55:01Z-
dc.date.issued2002-05-
dc.identifier.issn1098-6596-
dc.identifier.urihttp://sgc.anlis.gob.ar/handle/123456789/218-
dc.descriptionFil: Petroni, Alejandro. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio de Antimicrobianos; Argentina.es
dc.descriptionFil: Corso, Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio de Antimicrobianos; Argentina.es
dc.descriptionFil: Melano, Roberto. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio de Antimicrobianos; Argentina.es
dc.descriptionFil: Cacace, María Luisa. Hospital San Vicente de Paul; Argentina.es
dc.descriptionFil: Bru, Ana María. Hospital Juan D. Perón; Argentina.es
dc.descriptionFil: Rossi, Alicia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio de Antimicrobianos; Argentina.es
dc.descriptionFil: Galas, Marcelo F. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio de Antimicrobianos; Argentina.es
dc.description.abstractSince 1992 there have been seven major outbreaks of cholera in Argentina. Susceptibility analysis of 1,947 isolates (40% of reported cases) of Vibrio cholerae O1 biotype El Tor suggested the presence of extended-spectrum beta-lactamases (ESBLs) in 28 isolates. Because of their different susceptibility profiles, V. cholerae isolates M1502, M1516, M1573, and M3030 (all of which are of the Ogawa serotype) were selected for the present study. By susceptibility analysis, isoelectric focusing, and PCR-based restriction fragment length polymorphism analysis, CTX-M-type enzymes were identified in three isolates, whereas a PER-2-type enzyme, in addition to a TEM-1-like enzyme, was identified in the other isolate. The presence of these ESBLs in V. cholerae isolates resulted in MICs well below those commonly observed for members of the family ENTEROBACTERIACEAE: Genes that encode both ESBLs were transferred to Escherichia coli by conjugation, together with all determinants of resistance to non-beta-lactam antibiotics (gentamicin, kanamycin, and sulfamethoxazole for all isolates; amikacin and streptomycin for three isolates; trimethoprim, tetracycline, and chloramphenicol for two isolates). Plasmid profile analysis and Southern blotting revealed the presence of single plasmids of about 150 kb in the four V. cholerae isolates and their respective transconjugants and revealed that the plasmids harbored genes encoding CTX-M-type or PER-2-type ESBLs. These results strongly suggest the broad spread of these ESBLs among genera belong to families other than the ENTEROBACTERIACEAE:es
dc.formatpdfES
dc.language.isoenes
dc.relation.ispartofAntimicrobial agents and chemotherapyes
dc.rightsOpen Accessen_US
dc.rightsCreative Commons Attribution 4.0 International License-
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/-
dc.sourceAntimicrobial Agents and Chemotherapy 2002;46(5):1462–1468en_US
dc.subjectCóleraes
dc.subjectBrotes de Enfermedadeses
dc.subjectFarmacorresistencia Bacterianaes
dc.subjectbeta-Lactamasases
dc.subjectFocalización Isoeléctricaes
dc.subjectPlásmidoses
dc.subjectVibrio choleraees
dc.subjectArgentinaes
dc.titlePlasmidic extended-spectrum beta-lactamases in Vibrio cholerae O1 El Tor isolates in Argentinaes
dc.typeArtículoes
dc.coverageARGen_US
dc.identifier.doi10.1128/aac.46.5.1462-1468.2002-
anlis.essnrd1es
item.openairetypeArtículo-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
crisitem.author.deptServicio Antimicrobianos-
crisitem.author.deptDepartamento de Bacteriología-
crisitem.author.deptInstituto Nacional de Enfermedades Infecciosas (INEI)-
crisitem.author.deptAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.deptAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.deptInstituto Nacional de Enfermedades Infecciosas (INEI)-
crisitem.author.deptDepartamento de Bacteriología-
crisitem.author.deptServicio Antimicrobianos-
crisitem.author.deptPublic Health Ontario Laboratory-
crisitem.author.deptMaestría en Microbiología Molecular UNSM-ANLIS-
crisitem.author.deptAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.deptInstituto Nacional de Enfermedades Infecciosas (INEI)-
crisitem.author.orcid0000-0003-1177-7037-
crisitem.author.parentorgDepartamento de Bacteriología-
crisitem.author.parentorgInstituto Nacional de Enfermedades Infecciosas (INEI)-
crisitem.author.parentorgAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.parentorgAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.parentorgInstituto Nacional de Enfermedades Infecciosas (INEI)-
crisitem.author.parentorgDepartamento de Bacteriología-
crisitem.author.parentorgCentro Nacional Red de Laboratorios (CNRL)-
crisitem.author.parentorgAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
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