Please use this identifier to cite or link to this item:
http://sgc.anlis.gob.ar/handle/123456789/1800
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Montaner, Alejandro Daniel | es |
dc.contributor.author | Denichilo, Analía | es |
dc.contributor.author | Rodríguez, Juan Manuel | es |
dc.contributor.author | Fló, Juan | es |
dc.contributor.author | López, Ricardo Agustin | es |
dc.contributor.author | Pontoriero, Andrea | es |
dc.contributor.author | Savy, Vilma L. | es |
dc.contributor.author | Baumeister, Elsa | es |
dc.contributor.author | Frank, Ronald | es |
dc.contributor.author | Zorzopulos, Jorge | es |
dc.contributor.author | Elías, Fernanda | es |
dc.date.accessioned | 2020-12-02T14:30:29Z | - |
dc.date.available | 2020-12-02T14:30:29Z | - |
dc.date.issued | 2011-08 | - |
dc.identifier.issn | 2159-3345 | - |
dc.identifier.uri | http://sgc.anlis.gob.ar/handle/123456789/1800 | - |
dc.description | Fil: Montaner, Alejandro Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Centro de Ciencia y Tecnología "Dr. Cesar Milstein"; Argentina. | es |
dc.description | Fil: Denichilo, Analía. Fundación Pablo Cassará; Argentina. | es |
dc.description | Fil: Rodríguez, Juan Manuel. Fundación Pablo Cassará; Argentina. | es |
dc.description | Fil: Fló, Juan. Immunotech S.A.; Argentina. | es |
dc.description | Fil: López, Ricardo Agustin. Immunotech S.A.; Argentina. | es |
dc.description | Fil: Pontoriero, Andrea. ANLIS Dr.C.G.Malbrán. Instituto de Enfermedades Infecciosas; Argentina. | es |
dc.description | Fil: Savy, Vilma. ANLIS Dr.C.G.Malbrán. Instituto de Enfermedades Infecciosas; Argentina. | es |
dc.description | Fil: Baumeister, Elsa. ANLIS Dr.C.G.Malbrán. Instituto de Enfermedades Infecciosas; Argentina. | es |
dc.description | Fil: Frank, Ronald. Helmholtz Centre for Infection Research; Braunschweig, Alemania. | es |
dc.description | Fil: Zorzopulos, Jorge. Fundación Pablo Cassará; Argentina. | es |
dc.description | Fil: Elías, Fernanda. Fundación Pablo Cassará; Argentina. | es |
dc.description.abstract | Flu vaccines are partially protective in infants and elder people. New adjuvants such as immunostimulatory oligonucleotides (ODNs) are strong candidates to solve this problem, because a combination with several antigens has demonstrated effectiveness. Here, we report that IMT504, the prototype of a major class of immunostimulatory ODNs, is a potent adjuvant of the influenza vaccine in young adult and elderly rats. Flu vaccines that use virosomes or whole viral particles as antigens were combined with IMT504 and injected in rats. Young adult and elderly animals vaccinated with IMT504-adjuvated preparations reached antibody titers 20-fold and 15-fold higher than controls, respectively. Antibody titers remained high throughout a 120 day-period. Animals injected with the IMT504-adjuvated vaccine showed expansion of the anti-hemagglutinin antibody repertoire and a significant increase in the antibody titer with hemagglutination inhibition capacity when confronted to viral strains included or not in the vaccine. This indicates that the addition of IMT504 in flu vaccines may contribute to the development of significant cross-protective immune response against shifted or drifted flu strains. | es |
dc.language.iso | en | es |
dc.relation.ispartof | Nucleic acid therapeutics | es |
dc.rights | Closed Access | - |
dc.subject | Adyuvantes Inmunológicos | es |
dc.subject | Secuencia de Aminoácidos | es |
dc.subject | Anticuerpos | es |
dc.subject | Ensayo de Inmunoadsorción Enzimática | es |
dc.subject | Vacunas contra la Influenza | es |
dc.title | Addition of the immunostimulatory oligonucleotide IMT504 to a seasonal flu vaccine increases hemagglutinin antibody titers in young adult and elder rats, and expands the anti-hemagglutinin antibody repertoire | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1089/nat.2011.0284 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | Artículo | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.dept | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
crisitem.author.dept | Departamento de Virología | - |
crisitem.author.dept | Servicio de Virosis Respiratoria | - |
crisitem.author.dept | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.dept | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
crisitem.author.dept | Departamento de Virología | - |
crisitem.author.dept | Servicio de Virosis Respiratoria | - |
crisitem.author.parentorg | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.parentorg | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
crisitem.author.parentorg | Departamento de Virología | - |
crisitem.author.parentorg | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.parentorg | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
crisitem.author.parentorg | Departamento de Virología | - |
Appears in Collections: | Publicaciones INEI |
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