Please use this identifier to cite or link to this item:
http://sgc.anlis.gob.ar/handle/123456789/1784
DC Field | Value | Language |
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dc.contributor.author | Mendoza, Laura Patricia | es |
dc.contributor.author | Picconi, María Alejandra | es |
dc.contributor.author | Mirazo, Santiago | es |
dc.contributor.author | Mongelos, Pamela | es |
dc.contributor.author | Gimenez, Graciela | es |
dc.contributor.author | Basiletti, Jorge | es |
dc.contributor.author | Arbiza, Juan | es |
dc.date.accessioned | 2020-12-01T00:17:25Z | - |
dc.date.available | 2020-12-01T00:17:25Z | - |
dc.date.issued | 2013-07 | - |
dc.identifier.uri | http://sgc.anlis.gob.ar/handle/123456789/1784 | - |
dc.description | Fil: Mendoza, Laura. National University of Asunción. Department of Public Health and Epidemiology. Health Sciences Research Institute; Paraguay. | es |
dc.description | Fil: Picconi, María A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. | es |
dc.description | Fil: Mirazo, Santiago. University of the Republic. Faculty of Sciences. Virology Section; Uruguay. | es |
dc.description | Fil: Mongelós, Pamela. National University of Asunción. Department of Public Health and Epidemiology. Health Sciences Research Institute; Paraguay. | es |
dc.description | Fil: Giménez, Graciela. National University of Asunción. Department of Public Health and Epidemiology. Health Sciences Research Institute; Paraguay. | es |
dc.description | Fil: Basiletti, Jorge. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. | es |
dc.description | Fil: Arbiza, Juan. University of the Republic. Faculty of Sciences. Virology Section; Uruguay. | es |
dc.description.abstract | Objective: To determine the distribution of HPV-16 variants among Paraguayan women with different grades of cervical lesions. Methods: Sixty-seven HPV-16-positive cervical samples obtained from women attending health centers in Paraguay between March 2007 and April 2009 were examined, including 29 low-grade squamous intraepithelial lesion (LSIL), 29 high-grade squamous intraepithelial lesion (HSIL), 4 cervical cancer, and 5 normal cytology samples. The specimens were analyzed by PCR-directed sequencing of a 364-bp fragment of the long control region of HPV-16, and a phylogenetic tree was compiled with MEGA 5.0 software. Results: Most HPV-16 variants belonged to the European branch (82%); these variants were detected among 25 of 29 women with LSIL, 22 of 29 women with HSIL, 3 of 4 women with cervical cancer, and all women with normal cytology. Two isolates yielded new variants of the European branch with nucleotide substitutions at positions A7752C and A7810T. Non-European variants, such as African type 1 (1.5%) and Asian-American (16.5%), were detected only among women with cervical lesions (4/29, LSIL; 6/29, HSIL; 1/29, cervical cancer). These variants had at least 6 nucleotide substitutions adjacent to or within transcription factor binding sites. Conclusion: All branches of HPV-16 variants were detected among Paraguayan women with cervical lesions. | es |
dc.language.iso | en | es |
dc.publisher | Elsevier | es |
dc.relation | datasets | es |
dc.relation.ispartof | International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics | es |
dc.rights | Open Access | - |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.source | International Journal of Gynecology & Obstetrics 2013; 122(1):44-7 | - |
dc.subject | Adolescente | es |
dc.subject | Adulto | es |
dc.subject | Anciano | es |
dc.subject | Sitios de Unión | es |
dc.subject | Neoplasia Intraepitelial Cervical | es |
dc.subject | Femenino | es |
dc.subject | Papillomavirus Humano 16 | es |
dc.subject | Humanos | es |
dc.subject | Persona de Mediana Edad | es |
dc.subject | Nucleótidos | es |
dc.subject | Infecciones por Papillomavirus | es |
dc.subject | Paraguay | es |
dc.subject | Reacción en Cadena de la Polimerasa | es |
dc.subject | Análisis de Secuencia de ADN | es |
dc.subject | Factores de Transcripción | es |
dc.subject | Neoplasias del Cuello Uterino | es |
dc.subject | Adulto Joven | es |
dc.title | Distribution of HPV-16 variants among isolates from Paraguayan women with different grades of cervical lesion | es |
dc.type | Artículo | es |
dc.rights.license | Creative Commons Attribution 4.0 International License | - |
dc.identifier.doi | 10.1016/j.ijgo.2013.01.020 | - |
anlis.essnrd | 1 | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | Artículo | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.dept | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
crisitem.author.dept | Departamento de Virología | - |
crisitem.author.dept | Servicio Virus Oncogénicos | - |
crisitem.author.dept | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.dept | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
crisitem.author.dept | Departamento de Virología | - |
crisitem.author.dept | Servicio Virus Oncogénicos | - |
crisitem.author.dept | Maestría en Microbiología Molecular UNSM-ANLIS | - |
crisitem.author.parentorg | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.parentorg | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
crisitem.author.parentorg | Departamento de Virología | - |
crisitem.author.parentorg | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.parentorg | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
crisitem.author.parentorg | Departamento de Virología | - |
crisitem.author.parentorg | Centro Nacional Red de Laboratorios (CNRL) | - |
Appears in Collections: | Publicaciones INEI |
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