Treatment of Trypanosoma cruzi infection in the undetermined phase. Experience and current guidelines of treatment in Argentina

Abstract

The goals of specific treatment against Trypanosoma cruzi infection, at an individual level, are to eliminate the parasite, to diminish the probability of developing illness (Chagas disease), and to hinder the chain of T. cruzi transmission as actions for the control of vectorial and non vectorial transmission (Sosa Estani 1993). Around 1930, investigations began in Argentina to obtain an effective drug against T. cruzi. Of all the substances evaluated, only nifurtimox (1972) and benznidazol (1974) have been accepted by the Ministry of Health as anti-T. cruzi drugs. Both drugs began to be assessed on the acute phase, and later, on the chronic phase of the disease