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Title: Distinct monocyte subset phenotypes in patients with different clinical forms of chronic Chagas disease and seronegative dilated cardiomyopathy
Authors: Pérez-Mazliah, Damián E 
Castro Eiro, Melisa D 
Alvarez, María Gabriela 
Lococo, Bruno 
Bertocchi, Graciela 
Cesar, Gonzalo 
Natale, María A 
Albareda, María C 
Viotti, Rodolfo 
Laucella, Susana A. 
Issue Date: 2018
Journal: PLoS neglected tropical diseases 
Abstract: Chronic infection with Trypanosoma cruzi leads to a constant stimulation of the host immune system. Monocytes, which are recruited in response to inflammatory signals, are divided into classical CD14hiCD16-, non-classical CD14loCD16+ and intermediate CD14hiCD16+ subsets. In this study, we evaluated the frequencies of monocyte subsets in the different clinical stages of chronic Chagas disease in comparison with the monocyte profile of seronegative heart failure subjects and seronegative healthy controls. The effect of the anti-parasite drug therapy benznidazole on monocyte subsets was also explored.
DOI: 10.1371/journal.pntd.0006887
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