Please use this identifier to cite or link to this item:
http://sgc.anlis.gob.ar/handle/123456789/1333
DC Field | Value | Language |
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dc.contributor.author | López, Beatriz | es |
dc.contributor.author | Siqueira de Oliveira, Rosangela | es |
dc.contributor.author | Pinhata, Juliana M W | es |
dc.contributor.author | Chimara, Erica | es |
dc.contributor.author | Pacheco Ascencio, Edson | es |
dc.contributor.author | Puyén Guerra, Zully M | es |
dc.contributor.author | Wainmayer, Ingrid | es |
dc.contributor.author | Simboli, Norberto | es |
dc.contributor.author | Del Granado, Mirtha | es |
dc.contributor.author | Palomino, Juan Carlos | es |
dc.contributor.author | Ritacco, Viviana | es |
dc.contributor.author | Martin, Anandi | es |
dc.date.accessioned | 2019-11-21T20:28:45Z | - |
dc.date.available | 2019-11-21T20:28:45Z | - |
dc.date.issued | 2019-02-01 | - |
dc.identifier.uri | http://sgc.anlis.gob.ar/handle/123456789/1333 | - |
dc.description | Fil: López, Beatriz. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriologia; Argentina. | es |
dc.description | Fil: Siqueira de Oliveira, Rosangela. Instituto Adolfo Lutz Sao Paulo. Centro de Bacteriología. Nucleo de Tuberculose e Micobacterioses; Brasil. | es |
dc.description | Fil: Pinhata, Juliana M. W. Instituto Adolfo Lutz Sao Paulo. Centro de Bacteriología. Nucleo de Tuberculose e Micobacterioses; Brasil. | es |
dc.description | Fil: Chimara, Erica. Instituto Adolfo Lutz Sao Paulo. Centro de Bacteriología. Nucleo de Tuberculose e Micobacterioses; Brasil. | es |
dc.description | Fil: Pacheco Ascencio, Edson. Instituto Nacional de Salud. Laboratorio de Referencia Nacional de Micobacterias; Lima, Perú. | es |
dc.description | Fil: Puyén Guerra, Zully M. Instituto Nacional de Salud. Laboratorio de Referencia Nacional de Micobacterias; Lima, Perú. | es |
dc.description | Fil: Wainmayer, Ingrid. ANLIS Dr.C.G.Malbrán. Insituto Nacional de Enfermededades Infecciosas. Servicio de Micobacterias; Argentina. | es |
dc.description | Fil: Simboli, Norberto. ANLIS Dr.C.G.Malbrán. Insituto Nacional de Enfermededades Infecciosas. Servicio de Micobacterias; Argentina. | es |
dc.description | Fil: Del Granado, Mirtha. Pan American Health Organization; Estados Unidos. | es |
dc.description | Fil: Palomino, Juan Carlos. Ghent University. Department of Biochemistry and Microbiology. Faculty of sciences; Belgica. | es |
dc.description | Fil: Ritacco, Viviana. ANLIS Dr.C.G.Malbrán. Insituto Nacional de Enfermededades Infecciosas. Servicio de Micobacterias; Argentina. | es |
dc.description | Fil: Martín, Anandi. Université catholique de Louvain. Institute of Experimental and Clinical Research. Laboratory of Medical Microbiology; Belgica. | es |
dc.description.abstract | Objectives: To describe the distributions of bedaquiline and linezolid MIC values for the Mycobacterium tuberculosis WT population and to define the corresponding epidemiological cut-offs (ECOFFs) in three Latin American countries. Methods: MICs of bedaquiline and linezolid were determined by the resazurin microtitre assay (REMA). In phase 1, interlaboratory reproducibility was assessed using a panel of 10 fully susceptible M. tuberculosis strains. Phase 2 involved MIC determination for 248 clinical isolates from Argentina (n = 58), Brazil (n = 100) and Peru (n = 90) from patients who were treatment-naive for bedaquiline and linezolid. We then determined the ECOFFs for bedaquiline and linezolid by the eyeball method and the ECOFFinder statistical calculator. Results: Phase 1: REMA MIC values in the three sites were either identical to each other or differed by one 2-fold dilution from the consensus value with the exception of a single value. Phase 2: the bedaquiline MIC range was 0.0039-0.25 mg/L for pan-susceptible and drug-resistant isolates combined. The linezolid MIC range was 0.062-0.5 mg/L for pan-susceptible isolates and 0.031-4 mg/L for drug-resistant isolates. ECOFFs were 0.125 mg/L for bedaquiline and 0.50 mg/L for linezolid. Conclusions: REMA is reproducible and robust for the determination of bedaquiline and linezolid MIC distributions and ECOFF values when applied in laboratories of medium/low-resource countries. We suggest that WT MIC distributions for both drugs should be used as a monitoring tool to control the possible rapid emergence of resistance. | es |
dc.language.iso | en | es |
dc.relation.ispartof | The Journal of antimicrobial chemotherapy | es |
dc.subject | Tuberculosis Resistente a Múltiples Medicamentos | es |
dc.subject | Antituberculosos | es |
dc.subject | Mycobacterium tuberculosis | es |
dc.title | Bedaquiline and linezolid MIC distributions and epidemiological cut-off values for Mycobacterium tuberculosis in the Latin American region | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1093/jac/dky414 | - |
anlis.essnrd | 1 | - |
item.openairetype | Artículo | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
Appears in Collections: | Publicaciones INEI |
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