http://sgc.anlis.gob.ar/handle/123456789/13 2026-04-19T07:59:19Z http://sgc.anlis.gob.ar/handle/123456789/2376 Title: Neutralizing activity of Sputnik V vaccine sera against SARS-CoV-2 variants Authors: Ikegame, Satoshi; Siddiquey, Mohammed N A; Hung, Chuan-Tien; Haas, Griffin; Brambilla, Luca; Oguntuyo, Kasopefoluwa Y; Kowdle, Shreyas; Chiu, Hsin-Ping; Stevens, Christian S; Vilardo, Ariel Esteban; Edelstein, Alexis; Perandones, Claudia; Kamil, Jeremy P; Lee, Benhur Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected at least 180 million people since its identification as the cause of the current COVID-19 pandemic. The rapid pace of vaccine development has resulted in multiple vaccines already in use worldwide. The contemporaneous emergence of SARS-CoV-2 'variants of concern' (VOC) across diverse geographic locales underscores the need to monitor the efficacy of vaccines being administered globally. All WHO designated VOC carry spike (S) polymorphisms thought to enable escape from neutralizing antibodies. Here, we characterize the neutralizing activity of post-Sputnik V vaccination sera against the ensemble of S mutations present in alpha (B.1.1.7) and beta (B.1.351) VOC. Using de novo generated replication-competent vesicular stomatitis virus expressing various SARS-CoV-2-S in place of VSV-G (rcVSV-CoV2-S), coupled with a clonal 293T-ACE2 + TMPRSS2 + cell line optimized for highly efficient S-mediated infection, we determine that only 1 out of 12 post-vaccination serum samples shows effective neutralization (IC90) of rcVSV-CoV2-S: B.1.351 at full serum strength. The same set of sera efficiently neutralize S from B.1.1.7 and exhibit only moderately reduced activity against S carrying the E484K substitution alone. Taken together, our data suggest that control of some emergent SARS-CoV-2 variants may benefit from updated vaccines. Description: Fil. Ikegame, Satoshi. Departamento de Microbiología de la Escuela de Medicina Icahn en Mount Sinai, Nueva York, NY, EE. UU.; Fil. NA Siddiquey, Mohammed. Departamento de Microbiología e Inmunología, Universidad Estatal de Louisiana Health Shreveport, Shreveport, LA, EE. UU.; Fil. Chuan-Tien Hung. Departamento de Microbiología de la Escuela de Medicina Icahn en Mount Sinai, Nueva York, NY, EE. UU.; Fil. Griffin Haas. Departamento de Microbiología de la Escuela de Medicina Icahn en Mount Sinai, Nueva York, NY, EE. UU.; Fil. Brambilla, Luca. Departamento de Microbiología de la Escuela de Medicina Icahn en Mount Sinai, Nueva York, NY, EE. UU.; Fil. Kasopefoluwa Y Oguntuyo. Departamento de Microbiología de la Escuela de Medicina Icahn en Mount Sinai, Nueva York, NY, EE. UU.; Fil. Shreyas Kowdle, Departamento de Microbiología de la Escuela de Medicina Icahn en Mount Sinai, Nueva York, NY, EE. UU.; Fil. Hsin-Ping Chiu. Departamento de Microbiología de la Escuela de Medicina Icahn en Mount Sinai, Nueva York, NY, EE. UU.; Fil. Stevens, Christian S. Departamento de Microbiología de la Escuela de Medicina Icahn en Mount Sinai, Nueva York, NY, EE. UU.; Fil. Vilardo, Ariel Esteban. Administración Nacional de Laboratorios e Institutos de Salud de Argentina (ANLIS) Dr. Carlos G. Malbrán, Buenos Aires, Argentina.; Fil. Edelstein. Alexis. Administración Nacional de Laboratorios e Institutos de Salud de Argentina (ANLIS) Dr. Carlos G. Malbrán, Buenos Aires, Argentina.; Fil. Perandones, Claudia. Administración Nacional de Laboratorios e Institutos de Salud de Argentina (ANLIS) Dr. Carlos G. Malbrán, Buenos Aires, Argentina.; Fil. Kamil, Jeremy P. Departamento de Microbiología e Inmunología, Universidad Estatal de Louisiana Health Shreveport, Shreveport, LA, EE. UU.; Fil. Benhur Lee. Departamento de Microbiología de la Escuela de Medicina Icahn en Mount Sinai, Nueva York, NY, EE. UU. 2021-07-01T00:00:00Z http://sgc.anlis.gob.ar/handle/123456789/2306 Title: Prevalencia de defectos del tubo neural y estimación de casos evitados posfortificación en Argentina Authors: Bidondo, María Paz; Liascovich, Rosa; Barbero, Pablo; Groisman, Boris Abstract: Periconceptional intake of folic acid has demonstrated to be effective to reduce the frequency of neural tube defects, and food fortification has been one of the strategies implemented to increase it. An update is herein presented on the reduced prevalence of neural tube defect cases in the post-fortification period in Argentina and an estimation of cases averted in the 2005-2013 period as a result of this intervention. When comparing the prevalence observed in the post-fortification period to that reported in the pre-fortification period, anencephaly and encephalocele decreased by 66%, and spina bifida, by 47%, which were significant reductions. The estimated number of cases averted was higher for anencephaly, followed by spina bifida; encephalocele showed the lowest number of cases averted given that the prevalence of this defect was smaller. The decrease observed in the prevalence supports findings from previous studies on the impact of fortification. Description: Fil: Bidondo, María P. Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS); Argentina.; Fil: Liascovich, Rosa. Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS); Argentina.; Fil: Barbero, Pablo. Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS); Argentina.; Fil: Groisman, Boris. Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS); Argentina. 2015-01-01T00:00:00Z http://sgc.anlis.gob.ar/handle/123456789/2302 Title: Notificación de casos de tuberculosis en la República Argentina: Período 1980-2009 Authors: ANLIS Dr.C.G.Malbrán; Argentina. Ministerio de Salud de la Nación Description: Fil: ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Respiratorias. Departamento de Programas de Salud; Argentina.; Fil: Ministerio de Salud de la Nación; Argentina. 2012-01-01T00:00:00Z http://sgc.anlis.gob.ar/handle/123456789/2301 Title: Notificación de casos de tuberculosis en la República Argentina: Período 1980-2006 Authors: ANLIS Dr.C.G.Malbrán; Argentina. Ministerio de Salud de la Nación Description: Fil: ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Respiratorias. Departamento de Programas de Salud; Argentina.; Fil: Ministerio de Salud de la Nación; Argentina. 2007-01-01T00:00:00Z