Artículos http://sgc.anlis.gob.ar/handle/123456789/2475 2026-04-16T21:15:58Z 2026-04-16T21:15:58Z Gomes, Karina Degiuseppe, Juan Ignacio Morón, Paula Rivero, Karina Barrios Matthieur, Christian Paladino, Carolina Cuba, Facundo Haim, María Poklépovich, Tomás Javier Stupka, Juan A. http://sgc.anlis.gob.ar/handle/123456789/2649 2025-05-29T13:44:17Z 2025-02-05T00:00:00Z

Title: Multi-Province Outbreak of Acute Gastroenteritis Linked to Potential Novel Lineage of GII.17 Norovirus in Argentina in 2024 Authors: Gomes, Karina; Degiuseppe, Juan Ignacio; Morón, Paula; Rivero, Karina; Barrios Matthieur, Christian; Paladino, Carolina; Cuba, Facundo; Haim, María; Poklépovich, Tomás Javier; Stupka, Juan A. Abstract: Noroviruses represent one of the leading causes of outbreaks and sporadic acute gastroenteritis (AGE) cases across all age groups. Although the GII.4 norovirus has been identified as the primary cause of most AGE outbreaks, the transient predominance of other genotypes has been reported globally. In this study, we describe a multi-province AGE outbreak caused by a potential new lineage of norovirus GII.17[P17], which has been recently detected at a high incidence in the United States and Europe. An amino acid analysis of the major viral capsid protein revealed several substitutions in the hypervariable region compared to strains circulating in the mid-2010s, which could play a key role in immune evasion. This is the first report of the detection of these viruses in the Southern Hemisphere, underscoring the importance of maintaining active genomic surveillance in the context of increasing numbers of acute gastroenteritis outbreaks. Description: Fil: Gomes KA. Laboratory of Viral Gastroenteritis-ANLIS "Dr. Carlos G. Malbrán"; Ciudad Autónoma de Buenos; Argentina.; Fil: Degiuseppe JI. Laboratory of Viral Gastroenteritis-ANLIS "Dr. Carlos G. Malbrán",Ciudad Autónoma de Buenos; Argentina.; Fil: Morón PM. Laboratory of Viral Gastroenteritis-ANLIS "Dr. Carlos G. Malbrán",Ciudad Autónoma de Buenos; Argentina.; Fil: Rivero KA. Laboratory of Viral Gastroenteritis-ANLIS "Dr. Carlos G. Malbrán",Ciudad Autónoma de Buenos; Argentina.; Fil: Barrios Matthieur, Christian. Laboratory of Viral Gastroenteritis-ANLIS "Dr. Carlos G. Malbrán",Ciudad Autónoma de Buenos; Argentina.; Fil: Paladino C. National Center of Genomics and Bioinformatics-ANLIS "Dr. Carlos G. Malbrán"; Ciudad Autónoma de Buenos Aires; Argentina.; Fil: Cuba FG. National Center of Genomics and Bioinformatics-ANLIS "Dr. Carlos G. Malbrán"; Ciudad Autónoma de Buenos Aires; Argentina.; Fil: Haim MS. National Center of Genomics and Bioinformatics-ANLIS "Dr. Carlos G. Malbrán"; Ciudad Autónoma de Buenos Aires; Argentina.; Fil: Poklépovich Caride TJ. National Center of Genomics and Bioinformatics-ANLIS "Dr. Carlos G. Malbrán"; Ciudad Autónoma de Buenos Aires; Argentina.; Fil: Stupka JA. National Center of Genomics and Bioinformatics-ANLIS "Dr. Carlos G. Malbrán"; Ciudad Autónoma de Buenos Aires; Argentina.

2025-02-05T00:00:00Z Liu, Xiaoxiao Seidel, Judy E McDonald, Terrence Patel, Alka B Waters, Nigel Bertazzon, Stefania Shahid, Rizwan Marshall, Deborah A http://sgc.anlis.gob.ar/handle/123456789/2560 2023-04-06T19:54:19Z 2022-06-23T00:00:00Z

Title: Rural-Urban Disparities in Realized Spatial Access to General Practitioners, Orthopedic Surgeons, and Physiotherapists among People with Osteoarthritis in Alberta, Canada Authors: Liu, Xiaoxiao; Seidel, Judy E; McDonald, Terrence; Patel, Alka B; Waters, Nigel; Bertazzon, Stefania; Shahid, Rizwan; Marshall, Deborah A Abstract: Rural Canadians have high health care needs due to high prevalence of osteoarthritis (OA) but lack access to care. Examining realized access to three types of providers (general practitioners (GPs), orthopedic surgeons (Ortho), and physiotherapists (PTs)) simultaneously helps identify gaps in access to needed OA care, inform accessibility assessment, and support health care resource allocation. Travel time from a patient's postal code to the physician's postal code was calculated using origin-destination network analysis. We applied descriptive statistics to summarize differences in travel time, hotspot analysis to explore geospatial patterns, and distance decay function to examine the travel pattern of health care utilization by urbanicity. The median travel time in Alberta was 11.6 min (IQR = 4.3-25.7) to GPs, 28.9 (IQR = 14.8-65.0) to Ortho, and 33.7 (IQR = 23.1-47.3) to PTs. We observed significant rural-urban disparities in realized access to GPs (2.9 and IQR = 0.0-92.1 in rural remote areas vs. 12.6 and IQR = 6.4-21.0 in metropolitan areas), Ortho (233.3 and IQR = 171.3-363.7 in rural remote areas vs. 21.3 and IQR = 14.0-29.3 in metropolitan areas), and PTs (62.4 and IQR = 0.0-232.1 in rural remote areas vs. 32.1 and IQR = 25.2-39.9 in metropolitan areas). We identified hotspots of realized access to all three types of providers in rural remote areas, where patients with OA tend to travel longer for health care. This study may provide insight on the choice of catchment size and the distance decay pattern of health care utilization for further studies on spatial accessibility. Description: Fil: Liu, Xiaoxiao. Department of Community Health Science, Cumming School of Medicine, University of Calgary; Canadá; Fil: Seidel, Judy E. Department of Community Health Science, Cumming School of Medicine, University of Calgary; Canadá; Fil: McDonald, Terrence. Department of Community Health Science, Cumming School of Medicine, University of Calgary; Canadá; Fil: Patel, Alka B. Department of Community Health Science, Cumming School of Medicine, University of Calgary; Canadá; Fil: Waters, Nigel. Department of Geography, University of Calgary; Canadá; Fil: Bertazzon, Stefania. Department of Geography, University of Calgary; Canadá; Fil: Shahid, Rizwan. Department of Geography, University of Calgary; Canadá; Fil: Marshall, Deborah A. Department of Community Health Science, Cumming School of Medicine, University of Calgary; Canadá

2022-06-23T00:00:00Z Guillon, Marlène Mathonnat, Jacky Narantuya, Bayarmagnai Dorjmyagmar, Batbayar Enkhtsetseg, Enkhbold http://sgc.anlis.gob.ar/handle/123456789/2559 2023-04-06T19:53:47Z 2022-08-03T00:00:00Z

Title: Exploring the efficiency of primary health care provision in rural and sparsely populated areas: a case study from Mongolia Authors: Guillon, Marlène; Mathonnat, Jacky; Narantuya, Bayarmagnai; Dorjmyagmar, Batbayar; Enkhtsetseg, Enkhbold Abstract: Mongolia is facing serious challenges in the health sector and the macro-economic sphere that have important implications for health financing and the completion of universal health coverage. In this context, improving the efficiency of primary health care facilities is a critical issue. We study the efficiency of Soum Health Centres (SHCs) that provide primary care in rural Mongolia. Based on activity and resources data collected for all SHCs of Mongolia in 2017 and 2018 we estimate bias-adjusted efficiency scores. A double bootstrap truncated regression procedure is then used to study the factors associated with SHCs' efficiency. On average, SHCs could potentially engage in the same activity while reducing overall resource use by ∼23%. A comparatively higher population density and dependency ratio in the districts where they are located tend to favour SHCs' efficiency. Conversely, the higher the poverty rate in the soum, the lower the efficiency. We find a positive association between SHCs' efficiency and the proportion of doctors in the health workforce. The human resources allocation process and the capitation formula currently used to pay SHCs should be adjusted based on the size and socioeconomic/demographic characteristics of the population living in the catchment area of SHCs. Description: Fil: Guillon, Marlène. Montpellier Recherche en Economie, Université de Montpellier and Fellow, Ferdi, Fondation pour les Etudes et Recherches sur le Développement International; Francia; Fil: Mathonnat, Jacky. Centre d'Etudes et de Recherches sur le Développement International (CERDI) and Fondation pour les Etudes et Recherches sur le Développement International (FERDI), Université Clermont Auvergne; Francia; Fil: Narantuya, Bayarmagnai. Center for Health Development, Mongolian Ministry of Health; Mongolia; Fil: Dorjmyagmar, Batbayar. Head of Health Information Division, Center for Health Development, Mongolian Ministry of Health; Mongolia; Fil: Enkhtsetseg, Enkhbold. National Health Account Researcher, Health Economy and Policy Research Division, Center for Health Development, Mongolian Ministry of Health; Mongolia

2022-08-03T00:00:00Z Maglioco, Andrea Agüero, Facundo A Valacco, María Pía Valdez, Alejandra Juárez Paulino, M Fuchs, Alicia G http://sgc.anlis.gob.ar/handle/123456789/2558 2023-04-06T19:53:07Z 2022-06-13T00:00:00Z

Title: Characterization of the B-Cell Epitopes of Echinococcus granulosus Histones H4 and H2A Recognized by Sera From Patients With Liver Cysts Authors: Maglioco, Andrea; Agüero, Facundo A; Valacco, María Pía; Valdez, Alejandra Juárez; Paulino, M; Fuchs, Alicia G Abstract: Cystic echinococcosis (CE) is a zoonotic disease worldwide distributed, caused by the cestode Echinococcus granulosus sensu lato (E. granulosus), with an incidence rate of 50/100,000 person/year and a high prevalence in humans of 5-10%. Serology has variable sensitivity and specificity and low predictive values. Antigens used are from the hydatid fluid and recombinant antigens have not demonstrated superiority over hydatid fluid. A cell line called EGPE was obtained from E. granulosus sensu lato G1 strain from bovine liver. Serum from CE patients recognizes protein extracts from EGPE cells with higher sensitivity than protein extracts from hydatid fluid. In the present study, EGPE cell protein extracts and supernatants from cell colonies were eluted from a protein G affinity column performed with sera from 11 CE patients. LC-MS/MS proteomic analysis of the eluted proteins identified four E. granulosus histones: one histone H4 in the cell extract and supernatant, one histone H2A only in the cell extract, and two histones H2A only in the supernatant. This differential distribution of histones could reflect different parasite viability stages regarding their role in gene transcription and silencing and could interact with host cells. Bioinformatics tools characterized the linear and conformational epitopes involved in antibody recognition. The three-dimensional structure of each histone was obtained by molecular modeling and validated by molecular dynamics simulation and PCR confirmed the presence of the epitopes in the parasite genome. The three histones H2A were very different and had a less conserved sequence than the histone H4. Comparison of the histones of E. granulosus with those of other organisms showed exclusive regions for E. granulosus. Since histones play a role in the host-parasite relationship they could be good candidates to improve the predictive value of serology in CE. Description: Fil: Maglioco, Andrea. Universidad Abierta Interamericana (UAI), Centro de Altos Estudios en Ciencias Humanas y de la Salud (CAECIHS); Buenos Aires, Argentina; Fil: Agüero, Facundo A. Universidad Abierta Interamericana (UAI), Centro de Altos Estudios en Ciencias Humanas y de la Salud (CAECIHS); Buenos Aires, Argentina; Fil: Valacco, María Pía. Centro de Estudios Químicos y Biológicos por Espectrometría de Masas (CEQUIBIEM), Instituto de Química Biológica Ciencias Exactas y Naturales- Consejo Nacional de Investigaciones Científicas y Técnicas (IQUIBICEN-CONICET), Facultad de Ciencias Exactas y Naturales- Universidad de Buenos Aires (UBA); Buenos Aires, Argentina; Fil: Valdez, Alejandra Juárez. Universidad Abierta Interamericana (UAI), Centro de Altos Estudios en Ciencias Humanas y de la Salud (CAECIHS); Buenos Aires, Argentina; Fil: Paulino, Margot. Instituto Nacional de Parasitología "Dr Mario Fatala- Chaben", (Administración Nacional de Laboratorios e Institutos de Salud) ANLIS-Malbrán; Buenos Aires, Argentina; Fil: Fuchs, Alicia G. Universidad Abierta Interamericana (UAI), Centro de Altos Estudios en Ciencias Humanas y de la Salud (CAECIHS); Buenos Aires, Argentina

2022-06-13T00:00:00Z