DSpace Collection:http://sgc.anlis.gob.ar/handle/123456789/212024-03-23T19:16:03Z2024-03-23T19:16:03ZLidocaine reinforces the anti-inflammatory action of dexamethasone on myeloid and epithelial cells activated by inflammatory cytokines or SARS-CoV-2 infectionElizagaray, Maia LinaMazitelli, IgnacioPontoriero, AndreaBaumeister, ElsaDocena, GuillermoRaimondi, ClementeCorreger, EnriqueRumbo, Martínhttp://sgc.anlis.gob.ar/handle/123456789/24492022-08-17T16:48:35Z2022-08-07T00:00:00ZTitle: Lidocaine reinforces the anti-inflammatory action of dexamethasone on myeloid and epithelial cells activated by inflammatory cytokines or SARS-CoV-2 infection
Authors: Elizagaray, Maia Lina; Mazitelli, Ignacio; Pontoriero, Andrea; Baumeister, Elsa; Docena, Guillermo; Raimondi, Clemente; Correger, Enrique; Rumbo, Martín
Abstract: Severe cases of COVID-19 that require admission to the ICU and mechanical ventilation assistance show a high mortality rate with currently few therapeutic options available. Severe COVID-19 is characterized by a systemic inflammatory condition, also called "cytokine storm", which can lead to various multi-organ complications and ultimately death. Lidocaine, a safe local anesthetic that given intravenously is used to treat arrhythmias, has long been reported to have an anti-inflammatory and pro-homeostatic activity.2022-08-07T00:00:00ZCurrent situation of endemic mycosis in the Americas and the Caribbean: Proceedings of the first international meeting on endemic mycoses of the Americas (IMEMA)Caceres, Diego HEcheverri Tirado, Laura CBonifaz, AlexandroAdenis, AntoineGomez, Beatriz LFlores, Claudia Lizette BandaCanteros, Cristina ElenaSantos, Daniel WagnerArathoon, Eduardo GSoto, Elia RamirezQueiroz-Telles, FlavioSchwartz, Ilan SZurita, JeanneteDamasceno, Lisandra SerraGarcia, NatalyFernández, Norma BChincha, OmayraAraujo, PatriciaRabagliati, RicardoChiller, TomGiusiano, Gustavo Ehttp://sgc.anlis.gob.ar/handle/123456789/24482022-08-17T16:48:19Z2022-07-30T00:00:00ZTitle: Current situation of endemic mycosis in the Americas and the Caribbean: Proceedings of the first international meeting on endemic mycoses of the Americas (IMEMA)
Authors: Caceres, Diego H; Echeverri Tirado, Laura C; Bonifaz, Alexandro; Adenis, Antoine; Gomez, Beatriz L; Flores, Claudia Lizette Banda; Canteros, Cristina Elena; Santos, Daniel Wagner; Arathoon, Eduardo G; Soto, Elia Ramirez; Queiroz-Telles, Flavio; Schwartz, Ilan S; Zurita, Jeannete; Damasceno, Lisandra Serra; Garcia, Nataly; Fernández, Norma B; Chincha, Omayra; Araujo, Patricia; Rabagliati, Ricardo; Chiller, Tom; Giusiano, Gustavo E
Abstract: The Americas are home to biologically and clinically diverse endemic fungi, including Blastomyces, Coccidioides, Emergomyces, Histoplasma, Paracoccidioides and Sporothrix. In endemic areas with high risk of infection, these fungal pathogens represent an important public health problem.2022-07-30T00:00:00ZFuture-proofing and maximizing the utility of metadata: The PHA4GE SARS-CoV-2 contextual data specification packageGriffiths, Emma JTimme, Ruth EMendes, Catarina InêsPage, Andrew JAlikhan, Nabil-FareedFornika, DanMaguire, FinlayCampos, JosefinaPark, DanielOlawoye, Idowu BOluniyi, Paul EAnderson, DominiqueChristoffels, Alanda Silva, Anders GonçalvesCameron, RhiannonDooley, DamionKatz, Lee SBlack, AllisonKarsch-Mizrachi, IleneBarrett, TanyaJohnston, AnjanetteConnor, Thomas RNicholls, Samuel MWitney, Adam ATyson, Gregory HTausch, Simon HRaphenya, Amogelang RAlcock, BrianAanensen, David MHodcroft, EmmaHsiao, William W LVasconcelos, Ana Tereza RMacCannell, Duncan Rhttp://sgc.anlis.gob.ar/handle/123456789/24332022-06-29T13:30:46Z2022-01-01T00:00:00ZTitle: Future-proofing and maximizing the utility of metadata: The PHA4GE SARS-CoV-2 contextual data specification package
Authors: Griffiths, Emma J; Timme, Ruth E; Mendes, Catarina Inês; Page, Andrew J; Alikhan, Nabil-Fareed; Fornika, Dan; Maguire, Finlay; Campos, Josefina; Park, Daniel; Olawoye, Idowu B; Oluniyi, Paul E; Anderson, Dominique; Christoffels, Alan; da Silva, Anders Gonçalves; Cameron, Rhiannon; Dooley, Damion; Katz, Lee S; Black, Allison; Karsch-Mizrachi, Ilene; Barrett, Tanya; Johnston, Anjanette; Connor, Thomas R; Nicholls, Samuel M; Witney, Adam A; Tyson, Gregory H; Tausch, Simon H; Raphenya, Amogelang R; Alcock, Brian; Aanensen, David M; Hodcroft, Emma; Hsiao, William W L; Vasconcelos, Ana Tereza R; MacCannell, Duncan R
Abstract: The Public Health Alliance for Genomic Epidemiology (PHA4GE) (https://pha4ge.org) is a global coalition that is actively working to establish consensus standards, document and share best practices, improve the availability of critical bioinformatics tools and resources, and advocate for greater openness, interoperability, accessibility, and reproducibility in public health microbial bioinformatics. In the face of the current pandemic, PHA4GE has identified a need for a fit-for-purpose, open-source SARS-CoV-2 contextual data standard.
Description: Fil: Griffiths, Emma J. Faculty of Health Sciences, Simon Fraser University; Canada; Fil: Timme, Ruth E. Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park; USA; Fil: Mendes, Catarina Inês. Instituto de Microbiologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa; Portugal; Fil: Page, Andrew J. Microbes in the Food Chain, Quadram Institute Bioscience, Norwich; United Kingdom; Fil: Alikhan, Nabil-Fareed. Microbes in the Food Chain, Quadram Institute Bioscience, Norwich United Kingdom; Fil: Fornika, Dan. BC Centre for Disease Control Public Health Laboratory, Vancouver; Canada; Fil: Campos, Josefina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina; Fil: Park, Daniel. Infectious Disease and Microbiome Program, The Broad Institute of MIT and Harvard, Cambridge; USA; Fil: Olawoye, Idowu B. African Center of Excellence for Genomics of Infectious Diseases (ACEGID), Redeemer's University, Ede; Nigeria; Fil: Oluniyi, Paul E. Department of Biological Sciences, College of Natural Sciences, Redeemer's University, Ede; Nigeria; Fil: Anderson, Dominique. South African Medical Research Council Bioinformatics Unit, South African National Bioinformatics Institute, University of the Western Cape; South Africa; Fil: Christoffels, Alan. South African Medical Research Council Bioinformatics Unit, South African National Bioinformatics Institute, University of the Western Cape ;South Africa; Fil: Gonçalves da Silva, Anders. Microbiological Diagnostic Unit Public Health Laboratory, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne; Australia; Fil: Cameron, Rhiannon. Faculty of Health Sciences, Simon Fraser University; Canada; Fil: Dooley, Damion. Faculty of Health Sciences, Simon Fraser University; Canada; Fil: Katz, Lee S. Center for Food Safety, University of Georgia, Atlanta; USA; Fil: Black, Allison. Department of Epidemiology, University of Washington; USA; Fil: Karsch-Mizrachi, Ilene. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda; USA; Fil: Barrett, Tanya. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda; USA; Fil: Johnston, Anjanette. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda; USA; Fil: Connor, Thomas R. Organisms and Environment Division, School of Biosciences, Cardiff University; United Kingdom; Fil: Nicholls, Samuel M. University of Birmingham; United Kingdom; Fil: Witney, Adam A. Institute for Infection and Immunity, St George's, University of London; United Kingdom; Fil: Tyson, Gregory H. Center for Veterinary Medicine, U.S. Food and Drug Administration; USA; Fil: Tausch, Simon H. Department of Biological Safety, German Federal Institute for Risk Assessment; Germany; Fil: Raphenya, Amogelang R. Department of Biochemistry and Biomedical Sciences and the Michael G. DeGroote Institute for Infectious Disease Research, McMaster University; Canada; Fil: Alcock, Brian. Department of Biochemistry and Biomedical Sciences and the Michael G. DeGroote Institute for Infectious Disease Research, McMaster University; Canada; Fil: Aanensen, David M. Centre for Genomic Pathogen Surveillance, Wellcome Genome Campus; United Kingdom; Fil: Hodcroft, Emma. Biozentrum, University of Basel; Switzerland; Fil: Hsiao, William W L. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver; Canada; Fil: Vasconcelos, Ana Tereza R. Bioinformatics Laboratory National Laboratory of Scientific Computation LNCC/MCTI; Brazil; Fil: MacCannell, Duncan R. Office of Advanced Molecular Detection, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention; USA2022-01-01T00:00:00ZInvasive Streptococcus pneumoniae isolates from pediatric population in Argentina for the period 2006-2019. Temporal progression of serotypes distribution and antibiotic resistanceZintgraff, JonathanGagetti, PaulaNapoli, DanielaSanchez Eluchans, NahuelIrazu, LuciaMoscoloni, Maria AliciaRegueira, MabelLara, ClaudiaCorso, Alejandrahttp://sgc.anlis.gob.ar/handle/123456789/24232022-02-03T13:13:09Z2022-01-01T00:00:00ZTitle: Invasive Streptococcus pneumoniae isolates from pediatric population in Argentina for the period 2006-2019. Temporal progression of serotypes distribution and antibiotic resistance
Authors: Zintgraff, Jonathan; Gagetti, Paula; Napoli, Daniela; Sanchez Eluchans, Nahuel; Irazu, Lucia; Moscoloni, Maria Alicia; Regueira, Mabel; Lara, Claudia; Corso, Alejandra
Abstract: Streptococcus pneumoniae is a major cause of severe invasive disease associated with high mortality and morbidity worldwide. A total of 2908 pneumococcal isolates were analyzed between 2006 and 2019. Gold standard pneumococcal serotyping (the Neufeld-Quellung reaction) was performed to identify the serotypes associated with infection in children < 5 years in Argentina and agar dilution method was carried out to determine their profiles to 14 antimicrobial agents. In 2012, the 13-valent pneumococcal conjugate vaccine (PCV13) was included in the National Immunization Program. In this work we have analyzed the local epidemiology of invasive pneumococcal diseases before and after the introduction of this vaccine in order to understand the epidemiological relevance and impact of PCV13. During the periods compared in the present study there was a significant increase in the proportion of non-PCV13 serotypes, serogroup 24 (246.7%) and 12F (85.7%), and a significant decrease in PCV13 serotypes, including serotypes 14 (91.2%), 5 (95.6%) and 1 (84.6%) among others. Another observation was that serotypes 3 (7.4%) and 19A (4.9%) still remain among the most frequent serotypes despite being part of the PCV13 formulation. Regarding antimicrobial resistance, in the present study we observed an increase in erythromycin resistance during the period of study mainly associated to serotype 14 in the pre-PCV13 period and to serogroup 24 in the post-PCV13 period, which also was the major NVT serotype associated with antimicrobial resistance and MDR. Serotypes 14, 24A/B/F and 19A were in the first three places among isolates resistant to all the antibiotics tested. Our data highlight the importance of continuous surveillance to assess the impact of pneumococcal vaccines and the use of antibiotics in the dynamic of pneumococcal serotypes.2022-01-01T00:00:00Z